Theranostic potential of self-luminescent branched polyethyleneimine-coated superparamagnetic iron oxide nanoparticles

• Rouhollah Khodadust,
• Ozlem Unal and
• Havva Yagci Acar

Beilstein J. Nanotechnol. 2022, 13, 82–95, doi:10.3762/bjnano.13.6

• factor receptor (EGFR). Pro-apoptotic polyinosinic–polycytidylic acid sodium (PIC) was delivered to HeLa cells with SPION@bPEI and caused a dramatic reduction in the cell viability at otherwise non-toxic nanoparticle concentrations, proving that bPEI coating is still an effective component for the

• signal was demonstrated. Then, a pro-apoptotic oligonucleotide (polyinosinic–polycytidylic acid sodium salt) (PIC) was transfected into HeLa cells to demonstrate that luminescent bPEI coating is still an effective component for the delivery of an anionic cargo and it may deliver oligonucleotides in a

• nanoparticles (12.5 mg/mL) contain 380 µg Erb/mL. PIC and pGFP loading to luminescent magnetic nanoparticles (SPION@bPEI/PIC or SPION@bPEI/pGFP) Polyinosinic–polycytidylic acid sodium salt (Sigma-Aldrich, USA) was dissolved in nuclease-free water to a final concentration of 10 mg/mL. In order to make double